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Old 2021-09-22, 14:53   #1471
kriesel's Avatar
Mar 2017
US midwest

10111111101012 Posts

It's not necessarily an either/or. It would be sort of like chemotherapy; doses high enough for antiviral action are toxic.
In vitro, ivermectin has antiviral effects against several distinct positive-sense single-strand RNA viruses, including SARS-CoV-2.[87] Subsequent studies found that ivermectin could inhibit replication of SARS-CoV-2 in monkey kidney cell culture with an IC50 of 2.2–2.8 μM.[88][89] Based on this information, however, doses much higher than the maximum approved or safely achievable for use in humans would be required for an antiviral effect.[90][91] Aside from practical difficulties, such high doses are not covered by current human-use approvals of the drug and would be toxic, as the antiviral mechanism of action is considered to operate by the suppression of a host cellular process,[90] specifically the inhibition of nuclear transport by importin α/β1.[92][93] Self-medication with a highly concentrated formula intended for horses has led to numerous hospitalizations, and overdose can lead to death, possibly due to interaction with other medications.[94] To resolve uncertainties from previous small or poor-quality studies, as of June 2021, large scale trials are underway in the United States and the United Kingdom.[95][96]
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