If the case is roomy enough, a short PCIe riser might provide clearance over assorted obstacles on the motherboard.
But even without a riser, I've found some GPUs tall enough to require small accommodations like removing or repositioning the holddown block from an HP Z600 side cover.
3D printed blower adapters for some server style GPU models are often offered on eBay. (Most will serve on several model numbers.)
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